Fumio Hanaoka Selected Research

Pyrimidine Dimers

2/2012	Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1.
6/2010	Structure and mechanism of human DNA polymerase eta.
12/2004	DNA binding properties of human DNA polymerase eta: implications for fidelity and polymerase switching of translesion synthesis.
3/2004	Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.
5/2002	Translesion synthesis by human DNA polymerase eta across thymine glycol lesions.

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Fumio Hanaoka Research Topics

Disease

28	Xeroderma Pigmentosum (Kaposi's Disease) 01/2017 - 01/2002
15	Neoplasms (Cancer) 01/2019 - 11/2003
5	Skin Neoplasms (Skin Cancer) 05/2015 - 03/2004
5	Genomic Instability 02/2015 - 03/2003
5	Carcinogenesis 07/2010 - 10/2006
2	Hypersensitivity (Allergy) 01/2018 - 12/2005
2	Inborn Genetic Diseases (Disease, Hereditary) 10/2014 - 03/2002
2	Cockayne Syndrome (Syndrome, Cockayne) 11/2011 - 10/2002
2	Endometrial Neoplasms (Endometrial Cancer) 09/2004 - 05/2004
2	Complementation Group C Xeroderma Pigmentosum 10/2002 - 10/2002
1	Chromosomal Instability (Chromosome Stability) 01/2019
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2018
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 11/2012
1	Inflammation (Inflammations) 04/2008
1	Sarcoma (Soft Tissue Sarcoma) 10/2006
1	Chromosome Aberrations (Chromosome Abnormalities) 12/2005
1	Melanoma (Melanoma, Malignant) 12/2002
1	Male Infertility (Male Sterility) 02/2002

Drug/Important Bio-Agent (IBA)

14	Rad30 proteinIBA 06/2010 - 01/2002
13	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2002
12	Proteins (Proteins, Gene)FDA Link 01/2017 - 01/2002
8	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 01/2018 - 03/2002
5	Pyrimidine DimersIBA 02/2012 - 05/2002
4	DNA AdductsIBA 03/2010 - 05/2004
2	A-Form DNA (A-DNA)IBA 06/2010 - 03/2002
2	Cisplatin (Platino)FDA LinkGeneric 03/2010 - 04/2006
2	PlatinumIBA 03/2010 - 06/2005
2	DNA Polymerase I (Klenow Fragment)IBA 12/2005 - 04/2004
1	Pharmaceutical PreparationsIBA 01/2019
1	CamptothecinIBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2018
1	Ataxia Telangiectasia Mutated ProteinsIBA 01/2018
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2018
1	Sirtuin 3IBA 01/2018
1	Sirtuin 2IBA 01/2018
1	Small Interfering RNA (siRNA)IBA 01/2018
1	MutagensIBA 01/2018
1	Methoxsalen (Oxsoralen)FDA Link 11/2012
1	Hydroxyl RadicalIBA 11/2012
1	Superoxide DismutaseIBA 11/2012
1	Ligases (Synthetase)IBA 11/2011
1	2,4- bis(N,N'- di(carboxymethyl)aminomethyl)fluoresceinIBA 11/2011
1	Histone Deacetylases (Histone Deacetylase)IBA 04/2011
1	Histones (Histone)IBA 04/2011
1	DNA Glycosylases (DNA Glycosylase)IBA 07/2010
1	GuanineIBA 09/2009
1	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 09/2009
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2008
1	2'-deoxyxanthosineIBA 04/2008
1	A-factor (Streptomyces)IBA 04/2008
1	deoxyinosineIBA 04/2008
1	Biological ProductsIBA 01/2008
1	Telomere-Binding ProteinsIBA 02/2007
1	DNA Polymerase iotaIBA 10/2006
1	Gemcitabine FDA Link 04/2006
1	Cytarabine (Cytosar-U)FDA LinkGeneric 04/2006
1	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2005
1	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 07/2005
1	Telomerase (Telomerase Reverse Transcriptase)IBA 06/2005
1	EnzymesIBA 11/2004
1	ImmunosorbentsIBA 11/2004
1	EquileninIBA 09/2004
1	Benzo(a)pyreneIBA 06/2004
1	Estrogens (Estrogen)FDA Link 05/2004
1	Codon (Codons)IBA 11/2003
1	triphosphoric acid (triphosphate)IBA 03/2003
1	Thymine DNA GlycosylaseIBA 01/2003
1	DNA Polymerase beta (DNA Polymerase IV)IBA 12/2002
1	RNA (Ribonucleic Acid)IBA 10/2002
1	ThymineIBA 05/2002
1	UbiquitinIBA 02/2002

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 03/2010
1	Organ Transplantation 09/2005
1	Estrogen Replacement Therapy 09/2004